When premiered in January 1993 in the USA, the show became the highest rated series premiere in syndication history. It remains a consistent top ten performer in the US ratings.

The series has attracted a number of guest stars over the years including Oscar-winning actress Louise Fletcher plus Chris Sarandon, Mary Crosby, John Glover, Brian Keith, Iggy Pop and many more.

'Trials and Tribble-ations' was produced to commemorate the thirtieth anniversary of Star Trek. It features state-of-the-art Forrest Gump style technology which allowed the Deep Space Nine characters to merge with Kirk and his crew in the classic 'Troubles With Tribbles' from the Original Series.

Avery Brooks, who plays Captain Sisko, has done extensive work with the Smithsonian Institute's Program in Black American Culture.

Avery Brooks recognises that Deep Space Nine follows a grand humanitarian tradition within the Star Trek dynasty:
''Star Trek Deep Space Nine provides an opportunity to reinforce how critical it is to find a way to live together.''

Michael Dorn, who plays Lt. Commander Worf, has a long affiliation with Star Trek. He served for seven years on the Enterprise in The Next Generation before being transferred to Deep Space Nine as diplomatic liaison. He was also the first Next Generation crew member to appear in one of the Star Trek Features - playing his own grandfather in 'Star Trek VI - The Undiscovered Country.'.